SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
نویسندگان
چکیده
Cell-cell fusion allows viruses to infect neighboring cells without the need produce free virus and contributes tissue damage by creating virus-infected syncytia. Our results demonstrate that S2′ cleavage site is essential for activation TMPRSS2 unravel important differences between SARS-CoV SARS-CoV-2, among those, greater dependence of SARS-CoV-2 on ACE2 expression metalloproteases cell-cell fusion.
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2021
ISSN: ['1098-5514', '1070-6321', '0022-538X']
DOI: https://doi.org/10.1128/jvi.00002-21